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Under the auspices of the Coalition for National Trauma Research (of which, NTI is a member), the CLOTT group (Coalition of Leaders in Thromboembolism) received a grant from the Defense Medical Research and Development Program to conduct a new study: “The Pathogenesis of Post-Traumatic Pulmonary Embolism: A Prospective Multi-Center Investigation by the CLOTT Study Group.”

The CLOTT group has published papers documenting variances in practice and the impact of surveillance bias on the incidence of Deep Vein Thrombosis (DVT), as well as developed a venous thromboembolism (VTE)-specific data collection tool now uploaded to REDCap.

This study will focus on the significance of incidentally discovered pulmonary thrombi after injury as well as the role of fibrinogen breakdown in the development of post-traumatic Pulmonary Embolism.

CLOTT Investigators
-Peggy Knudson, MD, FACS, U. California, San Francisco (PI)

-Steve Shackford, MD, FACS, Scripps Mercy San Diego (Co-PI)
-Ernest “Gene” Moore, MD, FACS, U. Colorado (Co-PI)
-Frederick Rogers, MD, FACS Lancaster General Hospital
-Mark Cipolle, MD, FACS, Christiana CareHealth System
-David Mila, MD, Medical College of Wisconsin
-Bruce Crookes, MD, FACS, Medical U. South Carolina
-Elliot Haut, MD, PhD, FACS, Johns Hopkins
-John Holcomb, MD, FACS, U. TexasHealth Science Center, Houston
-Andy Kerwin, MD, FACS, U. Florida, Jacksonville
-Scott Brakenridge, MD, FACS U. Florida, Gainesville
-Lazlo Kiraly, U. Oregon, MD
-Ram Nirula, MD, PhD, FACS, U. Utah
-Todd Costantini, MD, FACS,  U. California, San Diego
-Tom Scalea, MD, FACS, U. Maryland/R Adams Cowley Shock Trauma Center
-George Velmahos, MD, PhD, FACS, Massachusetts General Hospital
-David Spain, MD, FACS, Stanford