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Mycoplasma Pneumoniae in the ICU

Principal Investigator: Joel Baseman, PhD
Lead Institution: University of Texas Health Science Center at San Antonio
Participating sites: University of Southern California, Massachusetts General Hospital and Yale

Mycoplasma pneumoniae is common in trauma patients with suspected ventilator-associated pneumonia (VAP) and contributes to pulmonary dysfunction. This multicenter prospective observational enrolled trauma patients with suspected VAP. The study had two specific aims: 1) determine the incidence of M. pneumoniae in mechanically ventilated intensive care unit (ICU) patients. The second aim was: 2) determine the impact of M. pneumoniae infection on ICU patient outcomes. Lavage fluid and serum samples were tested for M. pneumoniae. The study found that M. pneumoniae was present in a substantial number of study participants with suspected VAP. Participants who tested positive experienced a significantly longer ventilator course and worse oxygenation than those testing negative.

Publications

Muir MT, Cohn SM, Louden C, Kannan TR, Baseman JB. Novel toxin assays implicate Mycoplasma Pneumonia in prolonged ventilator course and hypoxemia. Chest. 2011 Feb; 139(2):305-310.
DOI: 10.1378/chest.10-1222